Timing Neonatal Hypoxic-Ischemic Encephalopathy

Therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy initiated within six hours after birth effectively prevents neurodevelopmental impairments in some but not all infants. In part, this may be related to the timing of hypoxia before relative initiation cooling. Metabolic acidosis at (suggesting acute hypoxia-ischemia) is required treatment with hypothermia. However, placental evidence suggests that infants also have chronic hypoxemia or poor perfusion birth. Furthermore, although fetal distress often noted during labor, inciting event difficult without a discrete sentinel (such as umbilical cord prolapse). Another potential method onset through evaluation nucleated red blood cell counts. Fetal induces production erythropoietin and then cells. These cells first appear 24-36 administration darbepoetin newborn infants,1Christensen R.D. Lambert D.K. Richards D.S. Estimating ‘emergence time’ neonates.J Perinatol. 2014; 34: 116-119https://doi.org/10.1038/jp.2013.113Crossref PubMed Scopus (20) Google Scholar suggesting elevated counts reflect hypoxic events least 24 earlier. volume The Journal Pediatrics, Bahr et al. report labor did (>95% age) normal were associated somewhat better outcomes. Further work area, perhaps combined biomarker studies evaluations, help researchers identify longer duration who respond therapeutic alone. Research on new therapies could targeted those are most likely benefit. Article page 12